The Pain Research Centre (PaRC)
The Royal London and St Bartholomew's Hospital, London
Publications
Over the years, members of the Pain Research Centre have contributed to a variety of publications - many of which have gone on to be appear in high impact journals. A list of these publications can be found below.
2025
Consenting for Spinal Cord Stimulation – The Pitfalls and Solution
Current Pain and Headache Reports 2025 Feb 29(1). doi:10.1007/s11916-024-01349-w.
Mehta V, Munglani R, Eyre G, Bajaj G, Abd-Elsayed A , Poply K
2024
Spinal Cord Stimulation Improves Quality of Life for Patients With Chronic Pain-Data From the UK and Ireland National Neuromodulation Registry
Neuromodulation 2024 Aug 15:S1094-7159(24)00646-9.
doi: 10.1016/j.neurom.2024.06.501.
Martin S.C, Baranidharan G, Thomson S, Gulve A, Manfield JH, Mehta V, Love-Jones S, Strachan R, Bojanic ́ S, Eldabe S, FitzGerald JJ
Five-Year Longitudinal Follow-Up of Restorative Neurostimulation Shows Durability of Effectiveness in Patients With Refractory Chronic Low Back Pain Associated With Multifidus Muscle Dysfunction
Neuromodulation 2024 Jul;27(5):930-943. doi:10.1016/j.neurom.2024.01.006. Epub 2024 Mar 12.
Gilligan C, Volschenk W, Russo M, Green M, Gilmore C, Mehta V, Deckers K, De Smedt K, Latif U, Sayed D, Georgius P, Gentile J, Mitchell B, Langhorst M, Huygen F, Baranidharan G, Patel V, Mironer E, Ross E, Carayannopoulos A, Hayek S, Gulve A, Van Buyten JP, Tohmeh A, Fischgrund J, Lad S, Ahadian F, Deer T, Klemme W, Rauck R, Rathmell J, Maislin G, Heemels JP, Eldabe S.
Differential Target Multiplexed Spinal Cord Stimulation: A UK Cost-Effectiveness Analysis
Neuromodulation. 2024 Jul;27(5):908-915. doi: 10.1016/j.neurom.2024.02.009.
Gulve A, Mehta V, Provenzano DA, Eggington S, Scheffler S, Gasquet NC, Ricker CN.
Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.
Lancet Child Adolesc Health. 2024 Mar;8(3):190-200. doi: 10.1016/S2352-4642(23)00316-4. Epub 2024 Jan 22.PMID: 38272046
RECOVERY Collaborative Group. (Wodehouse T)
Precision Rehabilitation After Neurostimulation Implantation for Multifidus Dysfunction in Nociceptive Mechanical Chronic Low Back Pain.
Archives of Rehabilitation Research and Clinical Translation. 2024 Mar 21;6(2):100333. doi: 10.1016/j.arrct.2024.100333. eCollection 2024 Jun.
Carayannopoulos A, Johnson D, Lee D, Giuffrida A, Poply K, Mehta V, Amann M, Santillo D, Ghandour Y, Koch A, Langhorst M, Heros R.
2023
Abducens Nerve Palsy - A Rare Complication of Spinal Cord Stimulator Insertion: Case Report and Literature Review.
Pain Medicine Case Reports. 2023 Dec;(7):361-372. doi: 10.36076/pmcr.2023.7.361
Chow V, Hari Narayanan AK, Poply K, Mehta V
Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Lancet Diabetes Endocrinol. 2023 Dec;11(12):905-914. doi: 10.1016/S2213-8587(23)00253-X. Epub 2023 Oct 18.PMID: 37865101
RECOVERY Collaborative Group. (Wodehouse T)
Dynamic Brain Imaging Response to Spinal Cord Stimulation Differential Frequencies DiFY SCS-PET Clinical Trial
Neuromodulation 2023 Jul;26(5):988-998. doi: 10.1016/j.neurom.2022.07.012. Epub 2022 Sep 21.
Poply K, Haroon A, Ganeshan B, Nikolic S, Sharma S, Ahmad A, Ellamushi H, Parsai A, Mehta V
Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Lancet. 2023 May 6;401(10387):1499-1507. doi: 10.1016/S0140-6736(23)00510-X. Epub 2023 Apr 13.PMID: 37060915
RECOVERY Collaborative Group. (Wodehouse T)
Long-term safety of spinal cord stimulation systems in a prospective, global registry of patients with chronic pain
Pain Management 2023 Feb;13(2):115-127. doi: 10.2217/pmt-2022-0091. Epub 2023 Jan 24.
Rauck et al. (Mehta V)
A Novel Pulsed Stimulation Pattern in Spinal Cord Stimulation: Clinical Results and Postulated Mechanisms of Action in the Treatment of Chronic Low Back and Leg Pain
Neuromodulation 2023 Jan;26(1):182-191. doi: 10.1016/j.neurom.2022.10.053. Epub 2022 Dec 9.
Desai MJ, Salmon J, Verrills P, Mitchell B, Du Toit N, Bates D, Vajramani G, Williams A, Love-Jones S, Patel N, Nikolic S, Mehta V, Ahmad A, Yu J, Christellis N, Harkin S, Baranidharan G, Levy R, Staats P, Malinowski MN, Makous J, Sullivan N, Kottalgi S, Hartley M, Mishra LN.
Three-Year Durability of Restorative Neurostimulation Effectiveness in Patients With Chronic Low Back Pain and Multifidus Muscle Dysfunction
Neuromodulation 2023 Jan;26(1):98-108. doi: 10.1016/j.neurom.2022.08.457. Epub 2022 Sep 27.
Gilligan C, Volschenk W, Russo M, Green M, Gilmore C, Mehta V, Deckers K, De Smedt K, Latif U, Sayed D, Georgius P, Gentile J, Mitchell B, Langhorst M, Huygen F, Baranidharan G, Patel V, Mironer E, Ross E, Carayannopoulos A, Hayek S, Gulve A, Van Buyten JP, Tohmeh A, Fischgrund J, Lad S, Ahadian F, Deer T, Klemme W, Rauck R, Rathmell J, Schwab F, Maislin G, Heemels JP, Eldabe S.
Long-Term Outcomes of Restorative Neurostimulation in Patients With Refractory Chronic Low Back Pain Secondary to Multifidus Dysfunction: Two-Year Results of the ReActiv8-B Pivotal Trial
Neuromodulation 2023 Jan;26(1):87-97. doi: 10.1016/j.neurom.2021.10.011. Epub 2021 Dec 18.
Gilligan C, Volschenk W, Russo M, Green M, Gilmore C, Mehta V, Deckers K, De Smedt K, Latif U, Georgius P, Gentile J, Mitchell B, Langhorst M, Huygen F, Baranidharan G, Patel V, Mironer E, Ross E, Carayannopoulos A, Hayek S, Gulve A, Van Buyten JP, Tohmeh A, Fischgrund J, Lad S, Ahadian F, Deer T, Klemme W, Rauck R, Rathmell J, Levy R, Heemels JP, Eldabe S; ReActiv8-B investigators.
2022
Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response.
Cell Rep Methods. 2022 Sep 19;2(9):100279. doi: 10.1016/j.crmeth.2022.100279. Epub 2022 Aug 12.PMID: 35975199
Doykov I, Baldwin T, Spiewak J, Gilmour KC, Gibbons JM, Pade C, Reynolds CJ, Áine McKnight, Noursadeghi M, Maini MK, Manisty C, Treibel T, Captur G, Fontana M, Boyton RJ, Altmann DM, Brooks T, Semper A; UK COVIDsortium Investigators (Wodehouse T); Moon JC, Kevin Mills, Heywood WE.
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis.
Lancet. 2022 Jul 30;400(10349):359-368. doi: 10.1016/S0140-6736(22)01109-6.
RECOVERY Collaborative Group. (Wodehouse T)
Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure.
Science. 2022 Jul 15;377(6603):eabq1841. doi:10.1126/science.abq1841
Reynolds CJ et al. (Wodehouse T)
HLA‐DR polymorphism in SARS‐COV‐2 infection and susceptibility to symptomatic COVID‐19
Immunology. 2022 May;166(1), pp. 68–77. doi:10.1111/imm.13450.
Astbury S, Reynolds CJ, Butler DK, Muñoz-Sandoval DC, Lin KM, Pieper FP, Otter A, Kouraki A, Cusin L, Nightingale J, Vijay A, Craxford S, Aithal GP, Tighe PJ, Gibbons JM, Pade C, Joy G, Maini M, Chain B, Semper A, Brooks T, Ollivere BJ, McKnight Á, Noursadeghi M, Treibel TA, Manisty C, Moon JC; COVIDsortium Investigators (Wodehouse T); Valdes AM, Boyton RJ, Altmann DM.
Effectiveness of high dose spinal cord stimulation for non-surgical intractable lumbar radiculopathy - HIDENS Study.
Pain Practice 2022 Feb;22(2):233-247. doi: 10.1111/papr.13087. Epub 2021 Nov 14.
Mehta V, Poply K, Ahmad A, Lascelles J, Elyas A, Sharma S, Ganeshan B, Ellamushi H, Nikolic S
Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Lancet. 2022 Feb 12;399(10325):665-676. doi: 10.1016/S0140-6736(22)00163-5. PMID: 35151397; PMCID: PMC8830904.
RECOVERY Collaborative Group (Wodehouse T)
Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Lancet 2022 Jan;399(10320):143–151. doi:10.1016/S0140-6736(21)01825-0.
RECOVERY Collaborative Group (Wodehouse T)
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.
Nature. 2022 Jan;601(7891):110-117. doi: 10.1038/s41586-021-04186-8. Epub 2021 Nov 10. PMID: 34758478; PMCID: PMC8732273.
Swadling L, Diniz MO, Schmidt NM, Amin OE, Chandran A, Shaw E, Pade C, Gibbons JM, Le Bert N, Tan AT, Jeffery-Smith A, Tan CCS, Tham CYL, Kucykowicz S, Aidoo-Micah G, Rosenheim J, Davies J, Johnson M, Jensen MP, Joy G, McCoy LE, Valdes AM, Chain BM, Goldblatt D, Altmann DM, Boyton RJ, Manisty C, Treibel TA, Moon JC; COVIDsortium Investigators (Wodehouse T); van Dorp L, Balloux F, McKnight Á, Noursadeghi M, Bertoletti A, Maini MK.
The Role and Impact of the Headache Nurse Specialist
Agri 2022 Jan;34(1):75-76. doi: 10.14744/agri.2020.67365.
Bhola R, Ertem DH
2021
Central sensitisation in chronic fatigue syndrome and fibromyalgia; a case control study.
Journal of Psychosomatic Research. 2021 Nov;150:110624. doi:10.1016/j.jpsychores.2021.110624. Epub 2021 Sep 21. PMID: 34600309.
Bourke JH, Wodehouse T, Clark LV, Constantinou E, Kidd BL, Langford R, Mehta V, White PD.
An implantable restorative-neurostimulator for refractory mechanical chronic low back pain: a randomized sham-controlled clinical trial
Pain 2021 Oct 1;162(10):2486-2498. doi: 10.1097/j.pain.0000000000002258.
Gilligan C, Volschenk W, Russo M, Green M, Gilmore C, Mehta V, Deckers K, De Smedt K, Latif U, Georgius P, Gentile J, Mitchell B, Langhorst M, Huygen F, Baranidharan G, Patel V, Mironer E, Ross E, Carayannopoulos A, Hayek S, Gulve A, Van Buyten JP, Tohmeh A, Fischgrund J, Lad S, Ahadian F, Deer T, Klemme W, Rauck R, Rathmell J, Levy R, Heemels JP, Eldabe S; ReActiv8-B investigators.
Real-World Outcomes Using a Spinal Cord Stimulation Device Capable of Combination Therapy for Chronic Pain: A European, Multicenter Experience.
Journal of Clinical Medicine. 2021 Sep 10;10(18):4085. doi: 10.3390/jcm10184085. PMID: 34575196; PMCID: PMC8466217
Kallewaard JW, Paz-Solis JF, De Negri P, Canós-Verdecho MA, Belaid H, Thomson SJ, Abejón D, Vesper J, Mehta V, Rigoard P, Maino P, Love-Jones S, Peña IF, Bayerl S, Perruchoud C, Bougeard R, Mertz C, Pei Y, Jain R.
Durability of the Therapeutic Effect of Restorative Neurostimulation for Refractory Chronic Low Back Pain.
Neuromodulation 2021 Aug;24(6):1024-1032. doi: 10.1111/ner.13477. Epub 2021 Jul 9.
Mitchell B, Deckers K, De Smedt K, Russo M, Georgius P, Green M, Gulve A, van Buyten JP, Smet I, Mehta V, Baranidharan G, Rathmell J, Gilligan C, Goss B, Eldabe S.
Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study.
Lancet Microbe. 2021 Oct;2(10):e508-e517. doi: 10.1016/S2666-5247(21)00146-4. Epub 2021 Jul 6. Erratum in: Lancet Microbe. 2021 Oct;2(10):e495. doi: 10.1016/S2666-5247(21)00185-3. PMID: 34250515; PMCID: PMC8260104.
Gupta RK, Rosenheim J, Bell LC, Chandran A, Guerra-Assuncao JA, Pollara G, Whelan M, Artico J, Joy G, Kurdi H, Altmann DM, Boyton RJ, Maini MK, McKnight A, Lambourne J, Cutino-Moguel T, Manisty C, Treibel TA, Moon JC, Chain BM, Noursadeghi M; COVIDsortium Investigators (Wodehouse T).
Conditioned pain modulation - A comprehensive review.
Neurophysiol Clin. 2021 Jun;51(3):197-208. doi: 10.1016/j.neucli.2020.11.002. Epub 2020 Dec 14.PMID: 33334645
Ramaswamy S, Wodehouse T.
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
Lancet. 2021 May 29;397(10289):2049-2059. doi: 10.1016/S0140-6736(21)00897-7. Epub 2021 May 14. PMID: 34000257; PMCID: PMC8121538.
RECOVERY Collaborative Group. (Wodehouse T)
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Lancet. 2021 May 1;397(10285):1637-1645. doi: 10.1016/S0140-6736(21)00676-0. PMID: 33933206; PMCID: PMC8084355.
RECOVERY Collaborative Group. (Wodehouse T)
Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose.
Science. 2021 Apr 30;372(6549):1418–23. doi: 10.1126/science.abh1282. Epub ahead of print. PMID: 33931567; PMCID: PMC8168614.
Reynolds CJ, Pade C, Gibbons JM, Butler DK, Otter AD, Menacho K, Fontana M, Smit A, Sackville-West JE, Cutino-Moguel T, Maini MK, Chain B, Noursadeghi M; UK COVIDsortium Immune Correlates Network; Brooks T, Semper A, Manisty C, Treibel TA, Moon JC; UK COVIDsortium Investigators (Wodehouse T); Valdes AM, McKnight Á, Altmann DM, Boyton R.
2020
Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19.
Wellcome Open Res. 2020 Oct 12;5:179. doi: 10.12688/wellcomeopenres.16051.2. eCollection 2020.PMID: 33537459
Augusto JB et al. (Wodehouse T)
Changes in peripheral and central sensitization in patients undergoing occipital nerve stimulation.
British Journal of Pain. 2020 Nov;14(4):250-255. doi: 10.1177/2049463719860548. Epub 2019 Jul 29.PMID: 33194189
Wodehouse T, Bahra A, Mehta V
Peripheral nerve stimulation registry for intractable migraine headache (RELIEF): a real-life perspective on the utility of occipital nerve stimulation for chronic migraine.
Acta Neurochir (Wien). 2020 Dec;162(12):3201-3211. doi: 10.1007/s00701-020-04372-z. Epub 2020 May 6. PMID: 32377948.
Ashkan K, Sokratous G, Göbel H, Mehta V, Gendolla A, Dowson A,
Wodehouse T, Heinze A, Gaul C.
The impact of the COVID-19 pandemic on patients awaiting spinal cord stimulation surgery in the United Kingdom: a multi-centre patient survey.
British Journal of Pain. 2020 Aug 21:2049463720948092. doi: 10.1177/2049463720948092. PMCID: PMC7443576.
Baranidharan G, Bretherton B, Eldabe S, Mehta V, Thomson S, Sharma ML, Vajramani G, Bojanic S, Gulve A, FitzGerald J, Hall S, Firth J.
Metabolic Imaging of Pain Matrix Using 18F Fluoro-deoxyglucose Positron Emission Tomography/Computed Tomography for Patients Undergoing L2 Dorsal Root Ganglion Stimulation for Low Back Pain.
Neuromodulation. 2020 Feb;23(2):222-233. doi: 10.1111/ner.13095.PMID: 32103593
Mehta V, Bouchareb Y, Ramaswamy S, Ahmad A, Wodehouse T, Haroon A.